Observations on the effects on rats of compounds related to acrylamide.

Barnes, J. M. (1970). Brit. J. industr. Med., 27, 147-149. Observations on the effects on rats of compounds related to acrylamide. Nine compounds (Table), close chemical relations of acrylamide, were given to adult rats both in their diet and as repeated daily doses by mouth. Dose rates were such that with acrylamide acute poisoning and neuropathy would have resulted. Seven of the compounds were without effect. N-methylacrylamide and N-hydroxymethylacrylamide produced some neurotoxic effects in large doses. The presence ofacrylamide as an impurity in the compound tested was not excluded.